Our rescue dog is a Belgian Mallinois mix who is extremely hyper and nervous at any loud noise. I have spent SO much money on tinctures ($80 per vial), treats ($45 a bag) from different manufacturers. We even had him on prescribed anti depressants. My friend who runs a dog adoption operation out of her home told me about these treats. For us, they are a miracle treat. At 65 lbs we started him with 2 treats, but that made him too mellow for a normal day. At first he was a little averse to the taste, but now he eats them like they are candy. We just give him 1 to 1 1/2 per, and he's fine - acts like himself, but less edgy. No weird after effects. We're very happy to have found something that helps our dog with his nerves!!